发明名称 Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
摘要 <p>This invention relates to the post-synthetic chemical modifications of RNA at the 2' -position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions. RNA interference (RNAi) is an evolutionarily conserved cellular mechanism of post-transcriptional gene silencing found in fungi, plants and animals that uses small RNA molecules to inhibit gene expression in a sequence-specific manner. The RNAi machinery can be harnessed to destruct any mRNA of a known sequence.</p>
申请公布号 AU2013361605(A1) 申请公布日期 2015.06.04
申请号 AU20130361605 申请日期 2013.12.18
申请人 SIRNA THERAPEUTICS, INC. 发明人 ZEWGE, DANIEL;COPELAND, GREGORY T.;LI, ZHEN;ARMSTRONG III, JOSEPH D.
分类号 A61K31/712 主分类号 A61K31/712
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