发明名称 |
Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA |
摘要 |
<p>This invention relates to the post-synthetic chemical modifications of RNA at the 2' -position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions. RNA interference (RNAi) is an evolutionarily conserved cellular mechanism of post-transcriptional gene silencing found in fungi, plants and animals that uses small RNA molecules to inhibit gene expression in a sequence-specific manner. The RNAi machinery can be harnessed to destruct any mRNA of a known sequence.</p> |
申请公布号 |
AU2013361605(A1) |
申请公布日期 |
2015.06.04 |
申请号 |
AU20130361605 |
申请日期 |
2013.12.18 |
申请人 |
SIRNA THERAPEUTICS, INC. |
发明人 |
ZEWGE, DANIEL;COPELAND, GREGORY T.;LI, ZHEN;ARMSTRONG III, JOSEPH D. |
分类号 |
A61K31/712 |
主分类号 |
A61K31/712 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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