1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF

摘要

Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.;

主权项

1. A method of treating a fibrotic disorder in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof: wherein: R1 is H; R2 is independently selected from the group consisting of H and —(C1-9 alkyl)nN(R9)2; R3 is H; R4 is independently selected from the group consisting of -aryl(R13)q, -furyl(R15)q, and -thiophenyl(R15)q; R5 is H; each R8 is a substituent attached to the heterocyclyl ring and independently selected from the group consisting of H, halide, and —C1-4 alkyl; each R9 is independently selected from the group consisting of H, —C1-9 alkyl, —(C1-3 alkyl)ncarbocyclyl and —(C1-9 alkyl)N(R16)2; each R13 is 1-2 substituents each attached to the aryl ring and independently selected from the group consisting of H, halide, —(C1-3 alkyl)nheterocyclyl(R8)q, —(C1-9 alkyl)nN(R9)2 and —(C1-9 alkyl)nNHSO2R18; each R15 is a substituent attached to the heteroaryl ring and independently selected from the group consisting of H, lower alkyl, halide, —CF3, CN, and —C(═O)(C1-3 alkyl); each R16 is independently selected from the group consisting of H and lower alkyl; each R18 is a lower alkyl; A is C; each q is independently an integer of 1 or 2; and each n is independently an integer of 0 or 1.