发明名称 |
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING BIGUANIDE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT |
摘要 |
<p>The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.</p> |
申请公布号 |
WO2015026215(A9) |
申请公布日期 |
2015.06.04 |
申请号 |
WO2014KR07898 |
申请日期 |
2014.08.25 |
申请人 |
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION |
发明人 |
CHO, MI-LA;YANG, CHUL-WOO;SHIN, DONG-YUN;PARK, MIN-JUNG;LEE, SEON-YEONG;LEE, SUNG-HEE;YANG, EUN-JI;SON, HYE-JIN;KIM, EUN-KYUNG;KIM, JAE-KYUNG |
分类号 |
A61K31/155;A61K31/36;A61P29/00 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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