| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing 4-(2,3-dimethylbenzyl)-1H-imidazole, also known as detomidine, having formula I: , which involves alkylation of trimethylsilyl imidazole with a compound of formula II: , where X: CI, Br, OH, in the presence of titanium tetrachloride in the medium of a chlorine-containing organic solvent, where molar ratio of titanium tetrachloride to N-trimethylsilyl imidazole must be maximum but must not be more than 0.95. ^ EFFECT: novel method of producing detomidine, characterised by high output of the end product. ^ 1 cl, 3 ex |
