发明名称 Method for improving blood flow using stilbenoid derivatives
摘要 The present invention generally provides methods for using stilbenoid derivatives to improve blood flow and microcirculation.
申请公布号 US9044491(B2) 申请公布日期 2015.06.02
申请号 US201113339150 申请日期 2011.12.28
申请人 The Board of Trustees of the University of Arkansas 发明人 Mayeux Philip R.;Holthoff Joseph H.
分类号 A61K31/7034;A61P9/10;A61P13/12 主分类号 A61K31/7034
代理机构 Polsinelli PC 代理人 Polsinelli PC
主权项 1. A method for improving renal blood flow and microcirculation during sepsis, the method comprising administering a monomer or an oligomer of a compound of Formula (I) to a subject experiencing sepsis such that renal blood flow and microcirculation of the subject are improved, the compound of Formula (I):wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are independently hydrogen, hydroxyl, hydrocarbyl, substituted hydrocarbyl, hydrocarbyloxy, substituted hydrocarbyloxy, or sulfoxy; provided that at least one of the R groups is a hydroxyl or substituted hydroxyl group; and provided that if the compound of Formula (I) is monomeric, then the compound of Formula (I) is other than a compound in which R1, R3, R5, R6, R7, and R10 are hydrogen, R2, R4, and R8 are independently hydroxyl, alkoxy, or glucosyloxy, and R9 is hydrogen or hydroxyl.
地址 Little Rock AK US