Substituted dioxopiperidinyl phthalimide derivatives

摘要

This invention relates to novel substituted dioxopiperidinyl phthalimide derivatives and pharmaceutically acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by an immunomodulatory agent.

主权项

1. A compound of Formula Ia: or a pharmaceutically acceptable salt thereof, wherein:
each of W1, W2, and W3 is independently selected from hydrogen or deuterium;each of Y1 and Y2 is independently selected from hydrogen or deuterium; andeach of Z1 Z2, Z3 and Z4 is independently selected from hydrogen or deuterium;wherein the compound comprises less than 25% of the other enantiomer, and wherein each position designated as D or deuterium has at least 75% incorporation of deuterium, and wherein any atom not designated as deuterium is present at its natural isotopic abundance.