Polymer compound for medical material, and biochip substrate using the polymer compound

摘要

A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface.;The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.

主权项

1. A polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance,
wherein the polymer has a reactive functional group which has a structure represented by the following general formula [4′] on at least one terminal side thereof; wherein the polymer is dissolved at a concentration of 0.05 to 10% by weight in a single solvent selected from ethanol, methanol, t-butyl alcohol, benzene, toluene, tetrahydrofuran, dioxane, dichloromethane, chloroform, acetone or methyl ethyl ketone or a mixed solvent thereof: wherein at least one of A1, A2 and A3 is a reacive moiety, selected from the group consisting of an alkoxyl group, a halogen group, an amino group, an isocyanate group, a phenoxy group and a hydroxyl group, the remainder of A1, A2, and A3 are each an alkyl group; and wherein R4 is an alkyl group having 1 to 20 carbon atoms,and wherein the functional group of the ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance is at least one functional group selected from an aldehyde group, an active ester group, an epoxy group, a vinylsulfone group, and biotin.