Biphenyl derivatives useful as glucagon receptor antagonists

摘要

The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

主权项

1. A compound of formula (I) wherein L1 is selected from the group consisting of —CH2—, —CH(CH3)— and —C(O)—; a is an integer from 0 to 3; each R1 is independently selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, fluorinated C1-4alkyl, C2-4alkenyl, C1-4alkoxy, fluorinated C1-4alkoxy, —SO2—(C1-2alkyl), —C(O)—C1-2alkyl, phenyl, C3-6cycloalkyl and C5-6cyaloalkenyl; b is an integer from 0 to 2; each R2 is independently selected from the group consisting of halogen, cyano, C1-4alkyl, fluorinated C1-4alkyl, C1-4alkoxy, fluorinated C1-4alkoxy and —C(O)—C1-2alkyl; c is an integer from 0 to 3; each R3 is independently selected from the group consisting of halogen, cyano, C1-4alkyl, fluorinated C1-4alkyl, C1-4alkoxy and fluorinated C1-4alkoxy; d is an integer from 0 to 4; each R4 is independently selected from the group consisting of halogen, cyano, nitro, C1-4alkyl, fluorinated C1-4alkyl, C1-4alkoxy, fluorinated C1-4alkoxy and —C(O)—C1-2alkyl; or a pharmaceutically acceptable salt thereof.