WAP DOMAIN FUSION POLYPEPTIDES AND METHODS OF USE THEREOF

摘要

This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins that include a WAP domain-containing polypeptide a second polypeptide, and a third polypeptide. The second and/or third polypeptides of the fusion proteins of the invention are a Fe polypeptide; an albumin polypeptide; a cytokine targeting polypeptide; or a serpin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.

主权项

1. An isolated fusion protein comprising at least one human whey acidic protein (WAP) domain-containing polypeptide operably linked to a second polypeptide, wherein the second polypeptide comprises at least one the following:
an immunoglobulin Fc polypeptide or an amino acid sequence that is derived from an immunoglobulin Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a serpin polypeptide or a sequence derived from a serpin polypeptide; or an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide.