发明名称 |
ARTIFICIAL DNA-BINDING PROTEINS AND USES THEREOF |
摘要 |
The present invention relates to proteins consisting of an artificial DNA-binding domain (DBD) and related molecules and uses thereof. In particular, the proteins are ZF-DBD or TALE-DBD and are used for the treatment of eye disorders caused by gain of function mutation. The disorder may be ADRP, in particular ADRP caused by mutation in the rhodopsin gene. The present invention also relates to a method to identify cis-regulatory elements and to modulate them via DBDs. |
申请公布号 |
CA2930282(A1) |
申请公布日期 |
2015.05.28 |
申请号 |
CA20142930282 |
申请日期 |
2014.11.20 |
申请人 |
FONDAZIONE TELETHON |
发明人 |
SURACE, ENRICO MARIA;MARROCCO, ELENA;BOTTA, SALVATORE |
分类号 |
C07K14/47;A61K48/00;C12N15/86;C12Q1/68 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|