发明名称 SODIUM CHANNEL BLOCKER DELIVERY SYSTEM WITH SCLERAL LENS
摘要 A scleral lens is provided with a sodium channel blocker or a sodium channel modulator disposed in the pre-corneal tear film between the scleral lens and the cornea. This system can be used to deliver sodium channel blockers or a sodium channel modulators not currently used because of poor bioavailability. Methods of using this sodium channel blocker delivery system or a sodium channel modulator delivery system are also disclosed.
申请公布号 US2015148899(A1) 申请公布日期 2015.05.28
申请号 US201514611421 申请日期 2015.02.02
申请人 Boston Foundation for Sight 发明人 ROSENTHAL Perry
分类号 A61K31/445;A61K9/00;A61F2/14;A61K31/165 主分类号 A61K31/445
代理机构 代理人
主权项 1. A method of treating corneal neuropathic pain in the eye of a patient, the method comprising: applying to the eye of a patient suffering from corneal neuropathic pain, a sodium channel modulator delivery system adapted for treatment of corneal neuropathic pain comprising: (a) a scleral lens to be disposed on an eye of a patient, the scleral lens comprising: an optic portion having a first curvature, and a scleral portion having a second curvature, wherein: (i) the first curvature is adapted to cover a cornea of the eye creating a reservoir between the first curvature and the cornea without any contact between the first curvature and the cornea, and(ii) the second curvature is adapted to align with the shape of a sclera of the eye, on which the second curvature rests; andalternating the administration of a solution comprising lacosamide with the administration of a solution comprising at least one of bupivacaine, lidocaine, proparacaine, flecainide, tetracaine, ropivacaine, levobupivacaine, carbamazepine, and amitriptyline at an alternation interval.
地址 Needham MA US