| 发明名称 |
VACCINE COMPOSITION FOR PREVENTING STAPHYLLOCOCCUS AUREUS INFECTION |
| 摘要 |
The present invention relates to a vaccine composition for preventing staphylococcus aureus infection containing, as an active ingredient, a ribitol-phosphate which has been modified only by a β-configuration in N-Acetylglucosamine (GlcNAc), a repeating unit of the ribitol-phosphate, or a wall teichoic acid (WTA) containing the repeating unit. The composition according to the present invention contains a coupling motif (an epitope) for an anti-WTA antibody, and thus can be effectively used as a vaccine composition or to prevent staphylococcus aureus infection by generating anti-WTA antibody. |
| 申请公布号 |
US2015147328(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201314399225 |
申请日期 |
2013.05.07 |
| 申请人 |
MOGAM BIOTECHNOLOGY INSTITUTE ;PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION |
发明人 |
Lee Bok Luel;Kenji Kurokawa;Jung Dong-Jun;An Jang-Hyun;Jeon Yu-Jin;Kim Na Hyang;Kazue Takahashi;Kim Eunmi;Ahn Dong Ho |
| 分类号 |
A61K39/085;C07K16/12 |
主分类号 |
A61K39/085 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vaccine composition for preventing staphylococcus aureus infection comprising a native form of WTA containing a ribitol-phosphate which has been modified by N-acetylglucosamine (GlcNAc), which comprises, as an active ingredient:
(i) a ribitol-phosphate which has been modified only by a β-configuration in GlcNAc and not by α-configuration; (ii) a repeating unit of the ribitol-phosphate which has been modified only by a β-configuration in GlaNAc and not by α-configuration; or (iii) WTA containing the repeating unit of the ribitol-phosphate which has been modified only by a β-configuration in GlaNAc and not by α-configuration. |
| 地址 |
Yongin-si, Gyeonggi-do KR |
