| 发明名称 |
CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER |
| 摘要 |
Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. |
| 申请公布号 |
US2015148397(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201514608981 |
申请日期 |
2015.01.29 |
| 申请人 |
Warsaw Orthopedic, Inc. |
发明人 |
Zanella John M.;Hobot Christopher M.;Biggs Danielle L.;Shaw Katara;McDonald Phillip Edward;King Vanja Margareta;McKay William F.;Remsen Kathy L. |
| 分类号 |
A61K31/4168;A61K9/00;A61K47/34 |
主分类号 |
A61K31/4168 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An implantable drug depot for reducing, preventing or treating pain in a patient in need of such treatment, the implantable drug depot comprising clonidine in an amount from about 1 wt. % to about 20 wt. % of the drug depot, and at least one biodegradable polymer, wherein the drug depot is capable of releasing clonidine over a period of at least three days. |
| 地址 |
Warsaw IN US |
