发明名称 |
Conditional replicating viral vectors |
摘要 |
<p>The present invention relates to a cytomegalovirus (CMV) which has been recombinantly altered to express a heterologous polypeptide and to allow for external control of viral replication. The heterologous polypeptide may be a polypeptide of interest such as an antigen, antibody or immune modulator. The CMV vectors of the invention are replication defective, or chemically controllable replication capable, or replication competent. The present invention also relates to uses of the CMV vectors such as inducing an immune response to an antigen or expressing an antibody or immune modulator in vivo. Compositions comprising the CMV expressing the heterologous polypeptide are also encompassed by the present invention.</p> |
申请公布号 |
AU2013355368(A1) |
申请公布日期 |
2015.05.28 |
申请号 |
AU20130355368 |
申请日期 |
2013.12.04 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
FU, TONG-MING;WANG, DAI;CASIMIRO, DANILO;FREED, DANIEL C.;LI, FENGSHENG |
分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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