Topical formulation for administering a compound

摘要

Embodiments of topical formulations for administering compound I or a pharmaceutically acceptable salt or solvate thereof are disclosed. Embodiments of methods for using the topical formulations in the treatment of dermatological disorders such as cutaneous collagen vascular diseases, e.g., cutaneous lupus, also are disclosed.;

主权项

1. A pharmaceutical ointment formulation for topical administration, comprising:
a therapeutically effective amount of from about 0.1% to about 10% (w/w) of compound I having a formulaor a pharmaceutically acceptable salt thereof;
from 15% to 40% (w/w) of a topical base comprising polyethylene glycol having an average molecular weight of from about 3000 to about 8000 daltons; from 0.5% to 1.5% (w/w) of an antioxidant; from 3% to 15% (w/w) of an emollient; from 10% to 20% (w/w) of a penetration enhancer; from 25% to 50% (w/w) of a water-miscible solvent; from 3% to 9% (w/w) of a surfactant; and from 0.05% to 0.25% (w/w) of a colorant.