SYSTEMIC DELIVERY AND REGULATED EXPRESSION OF PARACRINE GENES FOR CARDIOVASCULAR DISEASES AND OTHER CONDITIONS

摘要

In alternative embodiments the invention provides methods for treating ameliorating or protecting (preventing) an individual or a patient against a disease an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle a vector a recombinant virus or equivalent having contained therein a paracrine encoding nucleic acid or gene and the expression vehicle vector recombinant virus or equivalent can express the paracrine encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence or the expression vehicle vector recombinant virus or equivalent to an individual or a patient in need thereof thereby treating ameliorating or protecting (preventing) the individual or patient against the disease infection or condition responsive to an increased paracrine polypeptide level.