Non-Replicating Bacterial Nanoparticle Delivery System and Methods of Use

摘要

The present invention provides compositions and methods for the secretion and the translocation of a compound of interest by a bacterial minicell. In certain embodiments, the invention provides a bacterial minicell comprising at least one component of the type III secretion system (T3SS), which provides a safe and efficient system for secretion and translocation. In one embodiment, the invention allows for the delivery of an antigen to a cell or subject in order to induce an immune response.

主权项

1. A composition comprising a bacterial minicell comprising the components of the type III secretion system (T3SS) and a compound of interest, wherein the bacterial minicell secretes the compound of interest.