发明名称 |
CYCLIC ETHER DGAT1 INHIBITORSCYCLIC ETHER DGAT1 INHIBITORS |
摘要 |
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.; |
申请公布号 |
US2015141474(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
US201314396744 |
申请日期 |
2013.04.26 |
申请人 |
Patel Sejal;Mao Justin;Liu Qian;Harrison Tyler;Duvadie Rohit;Chen Xin;Zecri Frederic |
发明人 |
Patel Sejal;Mao Justin;Liu Qian;Harrison Tyler;Duvadie Rohit;Chen Xin;Zecri Frederic |
分类号 |
C07D413/12 |
主分类号 |
C07D413/12 |
代理机构 |
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代理人 |
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主权项 |
1. A compound according to formula (I) or a salt or solvate thereof: wherein X is O or CH; Y is O or CH; wherein one of X and Y is O and the other is CH; Z1, Z2, Z3 and Z4 are each, independently, N or CH; L is C(O) or absent; and A is a substituted oxazole, thiazole, oxadiazole or thiadiazole substituted with at least one C1-6alkyl, C3-7cycloalkyl or C1-6haloalkyl. |
地址 |
Lexington MA US |