发明名称 |
INHIBITION OF LEUKEMIC STEM CELLS BY PP2A ACTIVATING AGENTS |
摘要 |
A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula I: I wherein R1 is independently selected from hydrogen and methyl; R2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: II wherein R1 is a C6-C12 alkyl or C6-C12 alkoxy group; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and R3 is an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof. |
申请公布号 |
US2015141502(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
US201314404496 |
申请日期 |
2013.05.31 |
申请人 |
Ohio State Innovation Foundation |
发明人 |
Perrotti Danilo;Neviani Paolo |
分类号 |
A61K31/353;A61K31/137 |
主分类号 |
A61K31/353 |
代理机构 |
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代理人 |
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主权项 |
1. A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia, comprising administering a therapeutically effective amount of a composition including a compound of Formula I: wherein R1 is independently selected from hydrogen and methyl; R2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: wherein R1 is a C6-C12 alkyl or C6-C12 alkoxy group; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and R3 is a an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof. |
地址 |
Columbus OH US |