| 摘要 |
The invention relates to a process for the production of compounds of the formula <IMAGE> (I) in which R is hydrogen or optionally substituted alkyl, alkenyl, aralkyl or aryl, by microbiological transformation of <IMAGE> (X) follow by catalytic hydrogenation. The compounds obtained are useful for the treatment of diabetes, hyperlipoproteinaemia and adiposity which comprises aerobically cultivates, in the presence of an assimilable source of carbon nitrogen, at a temperature of 20 DEG to 45 DEG C. and pH between 2 and 10 and in the presence of an effective amount of a compound of the formula <IMAGE> (X) in which R has the above-given meaning and, R1 denotes an optionally substituted benzyl radical or an optionally substituted beta -alkenyl group, an aerobic microorganism or an extract of aerobic microorganism capable, in a nutrient medium containing a compound of the formula (X), or accumulating an amount of a compound of the formula <IMAGE> (XI) in which R and R1 have the above-mentioned meanings and subjecting the resulting compound of the general formula XI to catalytic hydrogenation. |
