发明名称 |
CHROMATOGRAPHIC MATERIALS |
摘要 |
The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition. W can be absent and/or can include hydrogen and/or can include hydroxyl on the surface of X. Q can be bound directly to X and can include a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. T can be bound directly to X and can include a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte. Additionally, Q and T can essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift or change) under chromatographic conditions utilizing low water concentrations. |
申请公布号 |
US2015136700(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
US201314401340 |
申请日期 |
2013.05.15 |
申请人 |
Waters Technologies Corporation |
发明人 |
Brousmiche Darryl W.;Wyndham Kevin D.;Fairchild Jacob N.;Iraneta Pamela C.;Hill Jason F. |
分类号 |
B01J20/283;B01D15/40;B01J20/22;B01J20/28;B01J20/30 |
主分类号 |
B01J20/283 |
代理机构 |
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代理人 |
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主权项 |
1. A chromatographic stationary phase material for normal phase chromatography, high-pressure liquid chromatography, solvated gas chromatography, supercritical fluid chromatography, sub-critical fluid chromatography, carbon dioxide based chromatography, hydrophilic interaction liquid chromatography or hydrophobic interaction liquid chromatography represented by Formula 1:
[X](W)a(Q)b(T)c Formula 1 wherein: X is a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof; W is absent and/or includes hydrogen and/or includes hydroxyl on the surface of X; Q is bound directly to X and comprises a first hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte; T is bound directly to X and comprises a second hydrophilic, polar, ionizable, and/or charged functional group that chromatographically interacts with the analyte; and Q and T essentially eliminate chromatographic interaction between the analyte, and X and W, thereby minimizing retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. |
地址 |
Milford MA US |