发明名称 |
ANIMAL MODEL FOR EPILEPSY AND METHOD FOR PRODUCING THE SAME |
摘要 |
The present invention relates to a technique for inducing epilepsy and a non-human animal model of epilepsy. More particularly, the present invention relates to a method for inducing epilepsy in an animal, a non-human animal model of epilepsy, and a method for manufacturing the same. |
申请公布号 |
US2015143560(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
US201414541252 |
申请日期 |
2014.11.14 |
申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ;YONSEI UNIVERSITY, UNIVERSITY --INDUSTRY FOUNDATION (UIF) |
发明人 |
LEE JEONG HO;KIM DONG SEOK;LIM JAE SEOK;KANG HOON CHUL |
分类号 |
A01K67/027;C12N9/12;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A non-human animal model of epilepsy, into which
an isolated protein consisting of an amino acid sequence which comprises one or more mutations selected from the group consisting of substitution of tyrosine (Y) for cysteine (C) at position 1483, substitution of arginine (R) for cysteine (C) at position 1483, substitution of lysine (K) for glutamic acid (E) at position 2419, substitution of glycine (G) for glutamic acid (E) at position 2419, substitution of proline (P) for leucine (L) at position 2427, and substitution of glutamine (Q) for leucine (L) at position 2427 in an amino acid sequence of SEQ ID NO. 2; or an isolated gene consisting of a nucleotide sequence which comprises one or more mutations selected from the group consisting of substitution of adenine (A) for guanine (G) at position 4448, substitution of cytosine (C) for thymine (T) at position 4447, substitution of adenine (A) for guanine (G) at position 7255, substitution of guanine (G) for adenine (A) at position 7256, substitution of cytosine (C) for thymine (T) at position 7280, and substitution of adenine (A) for thymine (T) at position 7280 in a nucleotide sequence of SEQ ID NO. 1 is introduced. |
地址 |
DAEJEON KR |