NOVEL COMPOUNDS AND METHODS FOR INHIBITING CELL DEATH

摘要

This invention provides novel compounds and methods for promoting cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule End Binding (EB) proteins and other associated proteins (e.g., drebrin). Methods for identifying potential modulators of cell death/plasticity are also described.

主权项

1. An isolated peptide, which (1) comprises a core amino acid sequence of (a) SKIP (SEQ ID NO:6); (b) SGIP (SEQ ID NO:7); (c) SRIP (SEQ ID NO:8); or (d) NAPVSxIPQ (SEQ ID NO:1) or a conservatively modified variant thereof; (2) has up to 40 amino acids at either or both of the N-terminus and the C-terminus of the core amino acid sequence; and (3) inhibits cell death or increases cell plasticity.