| 摘要 |
<p>Disclosed is an anti-cancer agent characterized by comprising at least one phosphine transition metal complex selected from compounds respectively represented by formulae (1a) to (1c). The anti-cancer agent has an equivalent anti-cancer activity to those of conventional anti-cancer agents and has low toxicity. [In the formulae, R1 and R2 independently represent a linear or branched alkyl group, a cycloalkyl group, a cyclcoalkyl group having a substituent, an adamantyl group, a phenyl group, or a phenyl group having a substituent, wherein each of R1 and R2 has 1 to 10 carbon atoms, R1 and R2 are different from each other, and R1 has a higher priority than R2 as ranked in accordance with the RS system; R3 and R4 independently represent a hydrogen atom, or a linear or branched alkyl group, wherein each of R3 and R4 has 1 to 6 carbon atoms, R3 and R4 may be the same as or different from each other, R3 and R4 may together form a saturated or unsaturated ring that may have a substituent; M represents a transition metal atom selected from the group consisting of gold, copper and silver; and X- represents an anion.]</p> |
