发明名称 |
PHARMACEUTICAL COMPOSITIONS CAPABLE OF INDUCING APOPTOSIS IN TUMOUR CELLS, USEFUL FOR DIAGNOSIS AND TREATMENT OF B-CHRONIC LYMPHOCYTIC LEUKAEMIA |
摘要 |
<p>The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions comprising a humanized monoclonal antibody recognizing the leukocyte differentiation antigen CD6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions comprising a humanized anti-CD6 monoclonal antibody for the diagnosis and treatment of Lymphoproliferative Syndromes and particularly the B-Cell Chronic Lymphocytic Leukemia. The essence of the invention consist in the application of a humanized Monoclonal Antibody that recognizes the CD6 antigen, the generation of pharmaceutical compositions comprising that antibody being able to induce apoptosis of malignant cells from B-Cell Chronic Lymphocytic Leukemia patients, reaching a clinical and a histological antitumor efficacy. The field of application of the present invention extends to the Oncology.</p> |
申请公布号 |
EP2119453(B1) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20070855984 |
申请日期 |
2007.12.24 |
申请人 |
CENTRO DE INMUNOLGÍA MOLECULAR |
发明人 |
MONTERO CASIMIRO, JOSÉ ENRIQUE;ALONSO RAMIREZ, RUBY;PEREZ RODRIGUES, ROLANDO |
分类号 |
A61K39/00;C07K16/28;G01N33/574 |
主分类号 |
A61K39/00 |
代理机构 |
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地址 |
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