发明名称 |
METHOD FOR DETECTING A MINORITY GENOTYPE |
摘要 |
Disclosed are methods for detecting a minority genotype of a target nucleic acid. The disclosed method generally includes the steps of (a) deep sequencing at least a portion of the target nucleic acid; (b) using the deep sequencing results of (a) to detect the presence of variant nucleobases at one or more nucleotide reference positions within the target nucleic acid; (c) using the variant detection results generated in step (b) to perform a statistical analysis of whether the variants are significant; and (d) using the variant detection and variant significance results generated in steps (b) and (c) to perform a statistical analysis of whether a subset of sequences together exhibit a common set of significant variants. |
申请公布号 |
EP2872649(A1) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20130740457 |
申请日期 |
2013.07.11 |
申请人 |
GEN-PROBE INCORPORATED |
发明人 |
DATTA, SOMALEE;BOWMAN, BRETT;WANG, XIANQUN;WANG, MINGJIE |
分类号 |
C12Q1/68;C12Q1/70 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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