Inhibitors of the shiga toxins trafficking through the retrograde pathway

摘要

The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.

主权项

1. A method of preventing and/or treating a disorder caused by a Shiga toxin or a related toxin, the method comprising administering to a subject in need thereof an affective amount of a benzodiazepine derivative compound of the formula (II): wherein: R3 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C1-C6 acyloxy group, an aryloxy group, or a heteroaryloxy group, these groups being optionally substituted by a C1-C6 alkoxy group or a heteroaryloxy group; R4 is a phenyl group; R5 is a C1-C3 alkoxy group, a C1-C3 alkyl group, saturated or not, optionally substituted by a phenyl group, or a phenyl group-which is optionally substituted by at least one radical selected from the group consisting of —OH, a halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxy group, —NO2, —CF3, and R6 is an oxygen atom or one or two C1-C3 alkyl groups; and/or a pharmaceutically acceptable salt of the benzodiazepine derivative compound.