Biostable, multipurpose, microbicidal intravaginal devices

摘要

Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.

主权项

1. A biostable, multipurpose, microbicidal intravaginal device comprising a drug effective in treating a yeast or bacterial vaginal infection, the drug selected from the group consisting of miconazole, ketoconazole, fluconazole, butoconazole, tioconazole, clotrimazole, mitomycin, clindamycin, doxycycline, leflunamide, 5-fluorouracil, paclitaxel, and mycophenolic acid, the device being in the form of a ringed-mesh construct comprising a fiber-reinforced ring matrix encircling a fibrous mesh positioned within the ring matrix and adjoined thereto and held in the ring lumen;
wherein the fibrous mesh extends across and substantially covers the ring lumen; and wherein the ring matrix comprises a silicone reinforced with polyethylene terephthalate yarn and the mesh comprises a polyethylene terephthalate fabric.