发明名称 |
G protein coupled receptor protein and use thereof |
摘要 |
Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided. |
申请公布号 |
US9034327(B2) |
申请公布日期 |
2015.05.19 |
申请号 |
US200913322304 |
申请日期 |
2009.09.07 |
申请人 |
Korea Research Institute of Bioscience and Biotechnology |
发明人 |
Chung Kyung Sook;Won Mi Sun;Ahn Ji Won;Choi Jeong Hae;Yoo Hyang Sook;Yeom Young Il;Song Eun Young;Lee Hee Gu;Cheong Jae Hun;Kang Chang Mo |
分类号 |
G01N33/53;C07K14/705;G01N33/50 |
主分类号 |
G01N33/53 |
代理机构 |
Lathrop & Gage LLP |
代理人 |
Lathrop & Gage LLP ;Wilkins, Esq Andrew T.;Trinque, Esq Brian C. |
主权项 |
1. A method for the treatment of stomach cancer, comprising administering to a subject in need thereof an agent inhibiting the expression of a polynucleotide encoding a GPCR polypeptide having the amino acid sequence of SEQ ID NO: 1, wherein the stomach cancer over-expresses the GPCR polypeptide having the amino acid sequence of SEQ ID NO: 1. |
地址 |
Daejeon KR |