Anti-BCMA antibodies

摘要

This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for depleting naïve B cells, plasma cells, and memory B cells, and for treating B cell-related disorders, including lymphomas and autoimmune diseases.

主权项

1. An isolated antibody or antigen binding fragment thereof that binds to the polypeptide of SEQ ID NO:9, wherein the antibody or antigen binding fragment thereof comprises:
a) a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:1 and a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:2; b) a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:3 and a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:4, SEQ ID NO:11, or SEQ ID NO:12; c) a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:5 and a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:6; or d) a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:7 and a variable domain comprising CDR1, CDR2, and CDR3 of the amino acid sequence of SEQ ID NO:8.