| 发明名称 |
Connective tissue growth factor antibodies |
| 摘要 |
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney. |
| 申请公布号 |
US9034643(B2) |
申请公布日期 |
2015.05.19 |
| 申请号 |
US201213691356 |
申请日期 |
2012.11.30 |
| 申请人 |
FibroGen, Inc. |
发明人 |
Lin Al Y.;Neff Thomas B.;Oliver Noelynn A.;Usinger William R.;Wang Qingjian;Yeowell David A. |
| 分类号 |
C12P21/06;C12N15/12;C12N5/12;C12N15/13;C12N5/10;C07H21/04;C07K16/22;A61K39/00 |
主分类号 |
C12P21/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polynucleotide sequence comprising a sequence selected from the group consisting of:
(a) a polynucleotide sequence encoding SEQ ID NO:14; (b) a polynucleotide sequence encoding from amino acid 1 through amino acid 167 of SEQ ID NO:14; (c) SEQ ID NO:13; and (d) nucleotide 1 through nucleotide 501 of SEQ ID NO:13. |
| 地址 |
San Francisco CA US |
