Acyl piperidine inhibitors of soluble epoxide hydrolase

摘要

Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.

主权项

1. A compound selected from the group consisting of 1-(1-(2-methylbutyryl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, (S)-1-(1-(2-methylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, 1-(1-(2-ethylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, 1-(1-(2-ethylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, (S)-1-(1-(2-methylbutanoyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea, 1-cyclohexyl-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-cycloheptyl-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-(4-isopropylphenyl)-3-(1-(2-methyl butanoyl)piperidin-4-yl)urea, 1-(3,5-di-trifluoromethylphenyl)-3-(1-(2-methylbutanoyl)piperidin-4-yl)urea, 1-(4-tert-butylphenyl)-3-(1-(2-methyl butanoyl)piperidin-4-yl)urea, 1-(4-ethylcyclohexyl)-3-(1-isobutyrylpiperidin-4-yl)urea, or salts thereof.