发明名称 |
DNA methylation biomarkers of post-partum depression risk |
摘要 |
<p>The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes: non-monocytes.</p> |
申请公布号 |
AU2013337353(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
AU20130337353 |
申请日期 |
2013.11.04 |
申请人 |
UNIVERSITY OF MARYLAND;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
KAMINSKY, ZACHARY;PAYNE, JENNIFER L.;GOULD, TODD |
分类号 |
C12Q1/68;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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