| 摘要 |
The present invention relates to biological materials against P2X7 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the biological materials of the present invention inhibit the biological activity of the P2X7 receptor, such as activation by ATP. |
| 主权项 |
1. A polypeptide comprising at least one immunoglobulin single variable domain that can bind P2X7, in particular human P2X7 (SEQ ID NOs: 1-3), with a Kd of less than 50 nM for use in treating P2X7 associated diseases, wherein the binding of said immunoglobulin single variable domain to said P2X7, in particular human P2X7 (SEQ ID NOs: 1-3), inhibits the activity of P2X7, in particular human P2X7 (SEQ ID NOs: 1-3),
wherein said P2X7 associated disease optionally is selected from the group consisting of multiple sclerosis, inflammatory bowel disease, neuropathic pain, epilepsy, stroke, diabetes, hypertension and cancer. |
