| 主权项 |
1. A compound according to Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
X is independently selected from O and NH; R1 is independently selected from carbocyclyl substituted with 1-5 R5, and heterocyclyl comprising carbon atoms and 1 to 3 heteroatoms selected from N, NR4, O, S, and substituted with 1-5 R5; R2 is independently selected from (i) alkyl optionally substituted with F, Cl, Br, ORb, CN, NRaRa, —C(═O)NRaRa, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, carbocyclyl substituted with 1-8 R7, and heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, NR6, O, S, and substituted with 1-8 R7, (ii) cycloalkyl substituted with 1-8 R7, and (iii) cycloheteroalkyl substituted with 1-8 R7; R3a, R3b, R3c, R3d, R3e and R3f are independently selected from H, CN, substituted with 1-3 R8, —C(═O)ORb, —C(═O)NRaRa, —C(═O)Rb, —NRaC(═O)Rb, —NRaC(═O)ORb, —(CH2)r-carbocyclyl substituted with 1-3 R8, and —(CH2)r-heterocyclyl substituted with 1-3 R8; alternatively, R3a and R3b, or R3c and R3d, or R3e and R3f, together with the carbon atom to which they are both attached form a spiral carbocyclic or heterocyclic ring comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S, each substituted with 1-5 R8; alternatively, R3a and R3c or R3b and R3d together form a heterocyclic ring comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S, and substituted with 1-5 R8; R4 is independently selected from H, C1-4 alkyl substituted with 0-3 Re, —(CH2)rCN, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(═O)Rb, —(CH2)rNRaRa, —(CH2)rC(═O)NRaRa, —(CH2)r—NRaC(═O)Rb, —(CH2)rNRaC(═O)ORb, —(CH2)rOC(═O)NRaRa, —(CH2)rNRaC(═O)NRaRa, —(CH2)rC(═O)ORb, —(CH2)rS(O)2NRaRa, —(CH2)rNRaS(O)2NRaRa, —(CH2)rNRaS(O)2Rc, (CH2)r-carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re; R5, at each occurrence, is independently selected from H, C1-4 alkyl substituted with 0-3 Re, F, Cl, Br, ═O, CN, NO2, —ORb, —(CH2)rCN, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(═O)Rb, —(CH2)rNRaRa, —(CH2)rC(═O)NRaRa, —(CH2)rNRaC(═O)Rb, —(CH2)rNRaC(═O)ORb, —(CH2)rOC(═O)NRaRa, —(CH2)rNRaC(═O)NRaRa, —(CH2)rC(═O)ORb, —(CH2)rS(O)2NRaRa, —(CH2)rNRaS(O)2NRaRa, —(CH2)rNRaS(O)2Re, (CH2)r-carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re; R6 is independently selected from H, —C(═O)Rb, —CO(═O)Rb, —S(O)pRc, C1-6 alkyl substituted with 0-5 Re, —(CH2)r—C3-6carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; R7, at each occurrence, is independently selected from H, F, Cl, Br, ═O, —(CRdRd)rCN, NO2, —(CRdRd)rORb, —S(O)pRc, —C(═O)Rb, —(CRdRd)rNRaRa, —(CRdRd)rC(═O)NRaRa, —NRaC(═O)Rb, —NRaC(═O)ORb, —OC(═O)NRaRa, —NRaC(═O)NRaRa, —(CRdRd)rC(═O)ORb, —S(O)2NRaRa, —NRaS(O)2NRaRa, —NRaS(O)2Rc, C1-6 alkyl substituted with 0-5 Re, —(CRdRd)r—C3-6carbocyclyl substituted with 0-5 Re, and —(CRdRd)r-heterocyclyl substituted with 0-5 Re; R8, at each occurrence, is independently selected from H, F, Cl, Br, CN, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl substituted with 0-5 Re, —(CH2)r-aryl substituted with 0-5 Re, —(CH2)r-heterocyclyl substituted with 0-5 Re, CO2H, —(CH2)rORb, and —(CH2)rNRaRa; Ra, at each occurrence, is independently selected from H, CN, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re; Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl; Rd, at each occurrence, is independently selected from H and C1-4alkyl substituted with 0-5 Re; Re, at each occurrence, is independently selected from F, Cl, Br, CN, NO2, ═O, C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, —(CH2)r-aryl, —(CH2)r-heterocyclyl, CO2H, —(CH2)rORf, SRf, and —(CH2)rNRfRf; Rf, at each occurrence, is independently selected from H, C1-5 alkyl optionally substituted with F, Cl, Br, C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl; p, at each occurrence, is independently selected from zero, 1, and 2; and r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4. |
