BORON-CONTAINING SMALL MOLECULES

摘要

This invention provides, among other things, novel compounds useful for treating bacterial infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

主权项

1. A compound having a structure according to the formula:wherein
R* is a member selected from H and a negative charge; R3 is a member selected from H, cyano, substituted or unsubstituted nitroalkyl and substituted or unsubstituted aminoalkyl; Ra is a member selected from H and —YR5 wherein
Y is a member selected from O and S;R5 is a member selected from H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl with the proviso that Ra and R3 cannot both be H; with the proviso that Ra and R*, together with the atoms to which they are attached, are optionally combined to form a 6- to 10-membered substituted or unsubstituted heterocycloalkyl ring; and with the proviso that when R3 is H, Ra does not have a structure which is a member selected from: unsubstituted benzyloxy, —OCH2COOH, methoxy, ethoxy, with the proviso that when Ra is H, R3 is not cyanoor a salt thereof.