发明名称 |
Labeled Alginate Conjugates For Molecular Imaging Applications |
摘要 |
Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents. |
申请公布号 |
US2015133645(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
US201514602504 |
申请日期 |
2015.01.22 |
申请人 |
Bellerophon BCM LLC |
发明人 |
Ruan Fuqiang;Deckwerth Thomas L.;Meglasson Martin D. |
分类号 |
C07D255/02;C07F1/08;C07F5/00 |
主分类号 |
C07D255/02 |
代理机构 |
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代理人 |
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主权项 |
1. A compound having the formula: wherein X is —(CH2)mC(O)—, with m being 1, 2, or 3; L is a linker selected from the group consisting of: wherein n, n′ and n″ are each independently a number from 0 to 10; H is hydrogen; and Y—H is: wherein R is selected from the group consisting of hydrogen, alkyl, benzyl or an aromatic group;or a pharmaceutically acceptable salt or solvate thereof. |
地址 |
Hampton NJ US |