摘要 |
Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.; |
主权项 |
1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:wherein:
R1 is H or F; R2 is H or F; R3 is OH or F; R4 is ON, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C4 cycloalkyl, azido, halogen, or C1-C2 haloalkyl, with the proviso that, when R3 is F, R4 is not methyl; R6 is OH; R5 is selected from the group of H and:wherein:
n′ is selected from 1, 2, 3, and 4; R8 is selected from C1-C8 alkyl, —O—C1-C8 alkyl, benzyl, —O-benzyl, —CH2—C3-C6 cycloalkyl, —O—CH2—C3-C6 cycloalkyl, and CF3; R9 is selected from phenyl, 1-naphthyl, 2-naphthyl, R10 is selected from H and CH3; R11 is selected from H or C1-C6 alkyl; R12 is selected from H, C1-C8 alkyl, benzyl, C3-C6 cycloalkyl, and —CH2—C3-C6 cycloalkyl. |