NOVEL COMPOUND, PREPARING METHOD THEREOF, AND USE THEREOF AS INHIBITORS OF HISTONE DEMETHYLASE

摘要

Provided are a novel compound, preparing method thereof, and use thereof as inhibitor of histone demethylase. The compound represented by Chemical Formula 1 has activity which inhibits histone demethylase and thus is capable of specifically and effectively inhibit activity of histone demethylase.

主权项

1. A compound represented by Chemical Formula 1, an isomer thereof, a derivative thereof, or a pharmaceutically acceptable salt thereof: wherein, R1 is hydrogen, a hydroxyl group, a ketone group, a halogen group, a substituted or unsubstituted C1 to C20 alkly group, a cyano group, or a combination thereof; R2, R3, R4, R5, R6, R7, and R8 are each independently hydrogen, a hydroxyl group, a halogen group, a cyano group, —C(═O)Ra, —C(═O)ORa, —OCO(ORa), —C═N(Ra), —SRa, —S(═O)Ra, —S(═O)2Ra, —PRa, a substituted or unsubstituted C1 to C20 alkly group, a substituted or unsubstituted C2 to C20 alkoxy group, a substituted or unsubstituted C2 to C20 alkenyl group, a substituted or unsubstituted C2 to C20 alkynyl group, a C2 to C20 alkylene oxide group, a substituted or unsubstituted C3 to C30 cycloalkyl group, a substituted or unsubstituted C6 to C30 aryl group, a substituted or unsubstituted C6 to C30 aryloxy group, a substituted or unsubstituted C6 to C30 heteroaryl group, or a combination thereof, where Ra is hydrogen, a C1 to C10 alkly group, or a C6 to C20 aryl group; and R3 is a halogen atom, or a C1 to C20 alkly group substituted with a halogen atom.