发明名称 |
QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS |
摘要 |
The Present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis. |
申请公布号 |
US2015133439(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
US201414327312 |
申请日期 |
2014.07.09 |
申请人 |
Millennium Pharmaceuticals, Inc. ;Kyowa Hakko Kirin Co., Ltd. |
发明人 |
Pandey Anjali;Scarborough Robert M.;Matsuno Kenji;Ichimura Michio;Nomoto Yuji;Ide Shinichi;Tsukuda Eiji;Sasaki Junko;Oda Shoji |
分类号 |
C07D239/94;C07D403/12 |
主分类号 |
C07D239/94 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
Cambridge MA US |