SURFACE FUNCTIONALIZATION OF SUPERPARAMAGNETIC NANOPARTICLES FOR BIOLOGICAL ENCAPSIDATION

摘要

Method and compositions are provided that relate to superparamagnetic nanoparticles, including IONP with small diameter and high transverse relaxivity, that are stable in an aqueous environment. The nanoparticle surface coating is functionalized, while minimizing its thickness, to facilitate packaging within biological constructs.

主权项

1. A method of generating functionalized superparamagnetic iron oxide nanoparticles (IONP) of small diameter and high transverse relaxivity, the method comprising:
suspending oleic-acid coated IONP in an organic solvent in the presence of an amphipathic molecule and an aqueous layer to generate an emulsion; sonicating the emulsion; centrifuging the sonicate to separate the layers; collecting the aqueous layer and functionalized nanoparticles comprises therein.