发明名称 |
Diagnostic, prognostic, therapeutic and screening protocols |
摘要 |
The specification describes an antibody capture process comprising (i) obtaining a biological sample comprising antibodies, (ii) contacting the biological sample with recombinant pIgR or a dIgA-binding variant, wherein the pIgR or variant binds dIgA and forms a pIgR-dIgA complex. The process may further comprise (iii) directly or indirectly assessing the level of the pIgR-dIgA complex or the level of a complex between pIgR-dIgA and an antigen of interest. There is also an antibody capture process for determining gut wall integrity in a test subject, wherein the level or ratio of SIgA to dIgA is compared to a corresponding level or ratio from a control subject. The specification provides kits embodying the process and recombinant pIgR when used for, or for use, in capturing or detecting dIgA and/or IgM. |
申请公布号 |
AU2013344322(A1) |
申请公布日期 |
2015.05.14 |
申请号 |
AU20130344322 |
申请日期 |
2013.11.08 |
申请人 |
THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD |
发明人 |
ANDERSON, DAVID ANDREW;GARCIA, MARY LOUISE;BARNES, NADINE CARMEL;HANAFIAH, KHAYRIYYAH MOHD;LANDAY, ALAN LEE |
分类号 |
G01N33/53;C12N15/12 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|