INTRATHECAL ADMINISTRATION OF MTOR INHIBITORS FOR THE THERAPY OF NEURODEGENERATIVE, NEUROINFLAMMATORY AND NEUROONCOLOGIC DISEASES

摘要

The invention relates to the use of inhibitors of the enzyme mTOR kinase (mammalian target of rapamycin) in the treatment of neuro-oncologic diseases, in particular tuberous sclerosis, neurodegenerative diseases, in particular Alzheimer's disease, and neuroinflammatory diseases, in particular multiple sclerosis and primary progressive aphasia, via intrathecal, or preferably intraventricular, administration of said inhibitors.

主权项

1. A method for the treatment, of pathologies selected from the group consisting of neurodegenerative diseases, neuroinflammatory diseases and tumour diseases with neurological involvement comprising intrathecally administering an effective amount of an mTOR inhibitor to a patient in need thereof.