Application of 5-HT₆receptor antagonists for the alleviation of cognitive deficits of down syndrome

摘要

Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.

主权项

1. A method of treating Down syndrome, comprising administering to a subject in need thereof an effective amount of a 5-HT6 receptor antagonist, wherein the 5-HT6 receptor antagonist is an effective amount of a compound selected from: compound 1, compound 2, compound 3, compound 4, compound 5, compound 6, and/or compound 7, having the chemical formula: or pharmaceutically acceptable hydrates, solvates, tautomers, salts and complexes thereof.