Bioadhesive for tissue repair

摘要

The invention provides a bioadhesive composition comprising a polysaccharide and an energy converter, wherein the energy converter is activated by non-UV light. The composition may be prepared by dissolving the polysaccharide and the energy converter in an aqueous acidic solution. The composition, in the form of a film or a gel, may be used for repairing a discontinuity in an area of tissue or for joining tissue.

主权项

1. A method for repairing a discontinuity in an area of tissue, said method comprising:
applying one or more light activatable bioadhesive films to the tissue such that said area of tissue to be repaired is partially or fully covered by said one or more films, wherein the one or more films comprises comprising a chitosan and an energy converter comprising indocyanine green and wherein the energy converter is activated by non-UV light, wherein said composition does not comprise a protein and wherein the energy converter is not activated by UV light irradiating said one or more films with non-UV light from a light source so as to increase adhesion between the film and the tissue, compared to tissue that has not been irradiated.