发明名称 Aminothiazole modulators of beta-3-adrenoreceptor
摘要 The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.;
申请公布号 US9029407(B2) 申请公布日期 2015.05.12
申请号 US201313921723 申请日期 2013.06.19
申请人 Auspex Pharmaceuticals, Inc. 发明人 Rao Tadimeti;Zhang Chengzhi
分类号 A61K31/425;C07D277/40;C07D277/22;A61K31/426;A61K45/06 主分类号 A61K31/425
代理机构 代理人 Bennett Dennis A.
主权项 1. A method of treatment of a disorder selected from the group consisting of overactive bladder, irritable bowel syndrome, type 2 diabetes, obesity, hyperglycemia, hyperlipemia, motility dysfunction, excessive gastrointestinal secretion, nonspecific diarrhea, triglyceridemia, retinopathy, nephropathy, neuropathy, cataracts, coronary heart diseases, arteriosclerosis, osteoporosis, atherosclerosis, hyperinsulinemia, depression, muscle wasting, urinary incontinence, and wound-healing, comprising the administration, to a patient in need thereof, of a therapeutically effective amount of a compound of structural Formula Ior a pharmaceutically acceptable salt thereof, wherein: R1-R24 are independently selected from the group consisting of hydrogen and deuterium; and at least one of R1-R24 is deuterium.
地址 La Jolla CA US