Substituted indazole derivatives active as kinase inhibitors

摘要

Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

主权项

1. A compound of formula (Ia), wherein: R is aryl substituted with one or more halogen; R1, R2 and R3 are hydrogen; Ar is aryl substituted with one or more NR5R6; and R5 and R6 are independently selected from hydrogen and optionally substituted heterocyclyl, or R5 and R6, taken together with the nitrogen atom to which they are bonded, form an optionally substituted heterocyclyl group; or a pharmaceutically acceptable salt thereof.