PTERIDINE KETONE DERIVATIVE AND APPLICATIONS THEREOF AS EGFR, BLK, AND FLT3 INHIBITOR

摘要

Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

主权项

1. A compound having the structure of general formula I: wherein, A and B are a benzene ring or five- or six-member heterocycle with various substituents; C is selected from any of the following groups: wherein X is selected from O, S and Se; R1 is a hydrogen, a halogen atom, a C1-C6 alkoxyl, an optionally substituted C1-C6 alkyl, an optionally substituted aryl or an optionally substituted aralkyl; each of R2 is independently selected from a hydrogen, a halogen, a C1-C6 alkoxyl, a hydroxyl, an optionally substituted acyloxy, an amino, an optionally substituted acylamino, an optionally substituted C1-C6 alkyl, CN, a sulfonate group, a sulfamoyl, a carbamoyl, a carboxyl, an optionally substituted alkoxyformyl, an optionally substituted phenyl, an optionally substituted N-alkylpiperazinyl, an optionally substituted morpholinyl, an optionally substituted piperidinyl, an optionally substituted pyrrolyl, optionally substituted pyrrolidinyl, —NRaRb, an optionally substituted pyridyl; each of R3 is independently selected from a hydrogen, a halogen, a C1-C6 alkoxyl, a hydroxyl, an optionally substituted acyloxy, an amino, an optionally substituted acylamino, an optionally substituted C1-C6 alkyl, CN, a sulfonate group, a sulfamoyl, a carbamoyl, a carboxyl, an optionally substituted alkoxyformyl, an optionally substituted phenyl, an optionally substituted N-alkyl piperazinyl, an optionally substituted morpholinyl, an optionally substituted piperidinyl, an optionally substituted pyrrolyl, an optionally substituted pyrrolidinyl, —NRaRb, and an optionally substituted pyridyl; Ra and Rb are independently selected from alkyl and alkenyl; and m and n are independently selected from 0, 1, 2, 3, or 4.