NITROGEN-CONTAINING BICYCLIC AROMATIC HETEROCYCLIC COMPOUND

摘要

[Problem] On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like is provided.;[Means for Solution] It was found that a nitrogen-containing bicyclic heterocyclic compound has the excellent cathepsin S inhibitory effect, thereby completing the invention. The compound of the present invention has the cathepsin S inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like.

主权项

1. A compound of formula (I) or a salt thereof: wherein X is CH or N; Y is CH, C-halogen, or N; W is —O— or —S(O)n—; L1 is a bond, -lower alkylene-, —O-lower alkylene-, —NH-lower alkylene-, or —C(O)-lower alkylene-; R1 is (i) lower alkyl which is optionally substituted with one or more substituents selected from the group consisting of a halogen, —OH, —O-lower alkyl, —NH2, —NH-(lower alkyl), —N(lower alkyl)2, —C(O)—NH2, —C(O)—NH-lower alkyl, —C(O)—N(lower alkyl)2, —C(O)—NH-nonaromatic heterocycle which is optionally substituted, —C(O)—N(lower alkyl))-nonaromatic heterocycle which is optionally substituted, a nonaromatic heterocycle which is optionally substituted, and —C(O)-nonaromatic heterocycle which is optionally substituted; (ii) nonaromatic heterocycle which is optionally substituted; or (iii) H; R2 is lower alkyl which is optionally substituted with a halogen, a halogen, or H; R3 is lower alkyl which is optionally substituted with a halogen, a halogen, or —CN; each R4 is independently lower alkyl which is optionally substituted with a halogen, —OH, —CN, or H; R5 is lower alkyl which is optionally substituted with a substituent selected from the group consisting of —OH, a halogen, —NH2, —NH-(lower alkyl), and —N(lower alkyl)2, —O-(lower alkyl which is optionally substituted with a halogen), C3-8 cycloalkyl which is optionally substituted, an aromatic heterocycle which is optionally substituted, or a nonaromatic heterocycle which is optionally substituted; and each n is independently an integer of from 0 to 2.