| 主权项 |
1. A method for promoting sensory hair cell regeneration comprising administering to a subject a compound in an amount effective to increase sensory hair cells in the subject, thereby promoting sensory hair cell regeneration in the subject, wherein the compound has the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein:
R1 is hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, or —SO2R8;R2 is hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, —C(═O)R8, —C(═O)OR8, or —C(═O)N(R8)2;or R1 and R2, taken together with the atoms to which they are attached, form an optionally substituted aryl or an optionally substituted cycloalkyl;R3 is hydrogen, optionally substituted C1-6alkyl, or optionally substituted aryl;R4, R5, and R6 are independently hydrogen, halo, optionally substituted C1-6alkyl, or optionally substituted C1-6alkoxy;or R4 and R5 taken together with the atoms to which they are attached, form an optionally substituted aryl;R7 is hydrogen or optionally substituted C1-6alkyl; andeach R8 is independently optionally substituted C1-6alkyl. |
